ISSN: 2148-4902 | E-ISSN: 2536-4553
Gastric hepatoid carcinoma: Report of a case [North Clin Istanb]
North Clin Istanb. 2021; 8(3): 314-316 | DOI: 10.14744/nci.2020.97720

Gastric hepatoid carcinoma: Report of a case

Metin Leblebici1, Cem Ilgın Erol1, Ozgur Ekinci1, Nesrin Gunduz2, Furkan Kilic1, Mehmet Acar1, Tunc Eren1, Rabia Burcin Girgin3, Orhan Alimoglu1
1Department of General Surgery, Istanbul Medeniyet University, Istanbul, Turkey
2Department of Radiology, Istanbul Medeniyet University, Istanbul, Turkey
3Department of Pathology, Istanbul Medeniyet University, Istanbul, Turkey

Gastric hepatoid carcinoma (GHC) is a rare type of gastric cancer with a tendency to have poor prognosis and metastasize to the liver. GHCs generally show histopathologically hepatocellular differentiation and secrete alpha fetoprotein (AFP). AFP production can occur in cancers originating from the embryologically similar liver, gastrointestinal tract, and yolk sac and often metastasizes to the liver. Although GHC is aggressive, it may not always cause liver metastasis and may invade into the other abdominal organs by direct contact. In this article, we present a case of locally advanced GHC with high AFP levels.

Keywords: Alpha fetoprotein protein, gastric cancer; gastric diseases; human.

Gastrik Hepatoid Karsinom: Olgu Sunumu

Metin Leblebici1, Cem Ilgın Erol1, Ozgur Ekinci1, Nesrin Gunduz2, Furkan Kilic1, Mehmet Acar1, Tunc Eren1, Rabia Burcin Girgin3, Orhan Alimoglu1
1İstanbul Medeniyet Üniversitesi, Genel Cerrahi Anabilim Dalı, İstanbul
2Radyoloji Anabilim Dalı, İstanbul Medeniyet Üniversitesi, İstanbul
3İstanbul Medeniyet Üniversitesi, Patoloji Anabilim Dalı, İstanbul

Gastric Hepatoid Carcinoma (GHC) is a rare type of gatric cancer with a tendency to have poor prognosis and metastasize to the liver. GHCs generally show histopathologically hepatocellular differentiation and secrete Alpha Fetoprotein (AFP). AFP production can occur in cancers originating from the embryologically similar liver, gastrointestinal tract and yolk sac and often metastasizes to the liver. Although GHC is aggressive, it may not always cause liver metastasis and may invade into the other abdominal organs by direct contact. In this article, we present a case of locally advanced GHC with high AFP levels. (NCI-2019-0339.R1)

Anahtar Kelimeler: Gastric cancer, AFP protein, human, Gastric diseases

Metin Leblebici, Cem Ilgın Erol, Ozgur Ekinci, Nesrin Gunduz, Furkan Kilic, Mehmet Acar, Tunc Eren, Rabia Burcin Girgin, Orhan Alimoglu. Gastric hepatoid carcinoma: Report of a case. North Clin Istanb. 2021; 8(3): 314-316

Corresponding Author: Metin Leblebici
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