North Clin Istanb. Ahead of Print: NCI-96236 | DOI: 10.14744/nci.2022.96236

The association of allergic rhinitis severity with neutrophil–lymphocyte and platelet–lymphocyte ratio in children

Murat Cansever¹, Neslihan Sari^2
1Mardin State Hospital, Department of Pediatrics, Division of Pediatric Allergy and Immunology, Mardin, TURKEY
²Mardin Artuklu University, Department of Otorhinolaryngology-Head and Neck Surgery, Mardin, TURKEY

Purpose: To investigate the relationship between the severity of allergic rhinitis (AR) and neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in pediatric patients.
Methods: This study is a retrospective cross-sectional observational study inclding 200 AR patients and 160 healthy controls. Of the patients, 39 % were boys with a mean age of 10.5 years. Study included children with persistent and intermittent AR. Of the controls, 50.6 % were boys with a mean age of 10.3 years. We compared NLR and PLR from blood test between study and control groups. They were also compared according to AR severity within the patient group.
Results: The NLR was 1,64±1,29 in the study group whereas 1,18±0,31 in the control group. The PLR was 102,72±31,20 in the study group whereas 79,36±11,72 in the control group. When NLR and PLR were compared between groups, we found statistically significant differences in both NLR and PLR (p=0.003, p=0.001, respectively). We found a statistically significant difference when comparing both NLR and PLR in patients with intermittent and persistent AR. These rates increased with disease severity (p=0.000, p=0.000, respectively).
Conclusion: Both NLR and PLR are useful markers for the diagnosis and severity of AR. Clinicians can use these markers to assess disease severity in pediatric patients at the beginning of the diagnostic process.

Keywords: Pediatric Allergic rhinitis, Aeroallergens, Neutrophil–lymphocyte ratio, Platelet–lymphocyte ratio

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Çocuklarda alerjik rinit þiddeti ile nötrofil-lenfosit ve trombosit-lenfosit oraný arasýndaki iliþki

Murat Cansever¹, Neslihan Sari^2
1Mardin Devlet Hastanesi, Çocuk Saðlýðý ve Hastalýklarý Anabilim Dalý, Çocuk Alerji ve Ýmmünoloji Bilim Dalý, Mardin
²Mardin Artuklu Üniversitesi, Kulak Burun Boðaz-Baþ Boyun Cerrahisi Anabilim Dalý, Mardin

Amaç: Pediyatrik hastalarda alerjik rinit (AR) þiddeti ile nötrofil-lenfosit oraný (NLO) ve trombosit-lenfosit oraný (PLR) arasýndaki iliþkiyi araþtýrmak.
Metod: Bu çalýþma, 200 AR hastasý ve 160 saðlýklý kontrolü içeren retrospektif kesitsel gözlemsel bir çalýþmadýr. Hastalarýn %39'u erkek ve ortalama yaþ 10.5 idi. Çalýþma, persistan ve aralýklý AR'li çocuklarý içeriyordu. Kontrollerin %50,6'sý, ortalama yaþlarý 10.3 olan erkek çocuklardý. Çalýþma ve kontrol gruplarý arasýnda kan testinden elde edilen NLR ve PLR'yi karþýlaþtýrdýk. Hasta grubu içinde AR þiddetine göre de karþýlaþtýrýldý.
Sonuçlar: NLR çalýþma grubunda 1,64±1,29 iken kontrol grubunda 1,18±0,31 idi. PLR çalýþma grubunda 102,72±31,20 iken kontrol grubunda 79,36±11,72 idi. Gruplar arasýnda NLR ve PLR karþýlaþtýrýldýðýnda, hem NLR hem de PLR'de istatistiksel olarak anlamlý farklýlýklar bulduk (sýrasýyla p=0,003, p=0,001). Aralýklý ve persistan AR'li hastalarda hem NLR hem de PLR'yi karþýlaþtýrýrken istatistiksel olarak anlamlý bir fark bulduk. Bu oranlar hastalýk þiddeti ile artýþ gösterdi (sýrasýyla p=0.000, p=0.000).
Sonuç: Hem NLR hem de PLR, AR'nin tanýsý ve þiddeti için faydalý belirteçlerdir. Klinisyenler, taný sürecinin baþlangýcýnda pediatrik hastalarda hastalýk þiddetini deðerlendirmek için bu belirteçleri kullanabilir. (NCI-2021-10-15/R1)

Anahtar Kelimeler: Pediatrik Alerjik rinit, Aeroalerjenler, Nötrofil-lenfosit oraný, Trombosit-lenfosit oraný

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