Analysis of the effects of COHb, lactate, and troponin levels on the clinical process and outcome in patients who were admitted to the emergency service due to carbon monoxide poisoning

INTRODUCTION: The aim of the present study was to determine the demographic, medical, and treatment characteristics of patients followed up with the diagnosis of carbon monoxide (CO) poisoning in emergency care and also to determine the relationship of these patients’ clinical process and outcome between carboxyhemoglobin (COHb), lactate, and troponin levels.
METHODS: The present study was conducted retrospectively between 01/01/2013 and 01/01/2016 by examining 450 patients who were referred to the emergency service for CO poisoning. The ages; sexualities; manners of application; clinical findings; levels of blood COHb, lactate, and troponin; applied oxygen treatment method; and outcome of patients were evaluated. Data analysis was done by Shapiro–Wilk, Student’s t, Mann–Whitney U, and chi-square tests.
RESULTS: A total of 450 patients were included in the study. The median age of the patients was 35 (interquartile range (IQR) 26.75–45.00) years. In the study where data are not homogeneously distributed, the median levels of COHb, lactate, and troponin were 11.80% (IQR 3–23), 1.60 (IQR 1.10–2.5) mmol/l, and 0.00 (IQR 0.000–0.003) ng/ml, respectively. The levels of lactate were detected to be statistically high in patients who had syncope and who received hyperbaric oxygen treatment (p<0.05). In addition, the levels of lactate and troponin were significantly higher in patients who were hospitalized (p<0.05).
DISCUSSION AND CONCLUSION: The levels of COHb, lactate, and troponin can provide an insight to the clinician about hospitalization and the type of treatment.

Karbonmonoksit Zehirlenmesi İle Acil Servise Başvuran Hastaların Demografik Özelliklerinin İncelenmesi

GİRİŞ ve AMAÇ: In this study, it is aimed to determine the relation among the demographical attributes the levels of carboxyhemoglobin, lactate and troponin and hospitalization duration of the patients who apply to the Emergency Room due to CO intoxication for the past three years.
YÖNTEM ve GEREÇLER: This study was carried out retrospectively between 01/01/2013 and 01/01/2016. The ages, sexualities, manners of application, etiology of intoxication, clinical findings, levels of blood carboxyhemoglobin (COHb), lactate and troponin, requirement of cranial computed tomography, applied treatments and the results of the patients are evaluated. The data analysis is done by Shapiro-Wilk, Student t test, Mann Whitney u and chi-square.
BULGULAR: A total of 450 patients (average age 37,5±14,0) were included in the study. It is detected that patients’ average levels of COHb, lactate and troponin levels were respectively 14,01±11,77 (95% CI: 12,92–15,10), 2,11±1,90 (95% CI: 1,93–2,28) mmol/L and 0,07±0,06 (95% CI 0,01–0,13) ng/ml.
Levels of lactate is detected statistically high in the patients who were transferred with an ambulance, who had syncope and who received hyperbaric oxygen treatment (p<0,05). And also, the levels of lactate and troponin were significantly higher in patients who had hospitalized (p <0,05)
TARTIŞMA ve SONUÇ: The levels of COHb, lactate and troponin can provide an insight to the clinician about hospitalization and the type of treatment.