Objective: Anaphylaxis is a life-threatening reaction in every age groups. The causative factors, incidence, and severity of anaphylaxis differ between children and adults. Literature on anaphylaxis during childhood is insufficient. We believe that the data of this study will make important contributions to the literature.
Methods: A retrospective analysis was conducted on patients aged 0-18 years who were admitted to the Pediatric Allergy Outpatient Clinic at Erciyes University between 2015 and 2021 and diagnosed with anaphylaxis.
Results: The majority of the patients were male. Females, however, exhibited greater prevalence during adolescence (p<0.001). Of the total number of patients, 153 (86.9%) had atopy, whereas 25.56% had non-allergic chronic diseases. Food-induced anaphylaxis was identified in 49 (27.84%) patients, drug-induced anaphylaxis in 41 (23.29%), venom-induced anaphylaxis in 62 (35.22%) and idiopathic anaphylaxis in 19. The study observed that anaphylaxis affected several systems, including the skin/mucosa (91.47%), respiratory (72.15%), GI (40.34%), CVS (20.45%), and CNS (17.04%).
It was also found that drug-induced anaphylaxis increased the severity of symptoms (p=0.003). Additionally, it was statistically significant that antibiotic-induced anaphylaxis (p=0.002) and wasp sting-induced anaphylaxis (p=0.003) developed within the first minute. Patients received intramuscular adrenaline in 95.46% of cases, while 4.54% did not receive appropriate treatment.
Conclusion: Anaphylaxis is a completely reversible reaction when diagnosed correctly and treated promptly. Therefore, it is essential to recognize the common triggers, know the risk factors, and provide patients with appropriate treatment. We believe that this study will contribute to better recognition of deficiencies in the management of anaphylaxis by highlighting important information for anaphylaxis.

Orta Anadolu’daki referans merkezin nedenleri, aðirliði ve tedavisi yönüyle çocukluk çaði anafilaksi deneyimi

Giriþ: Anafilaksi tüm yaþ gruplarý için hayatý tehdit edici ciddi bir reaksiyondur. Anafilaksi nedeni, sýklýðý ve aðýrlýðý çocuklarda ve yetiþkinlerde farklýlýk göstermektedir. Çocukluk çaðý anafilaksilerinde literatürdeki veriler yetiþkinlere göre yetersiz sayýdadýr. Bu nedenle bu çalýþmanýn literature katkýda bulunacaðýna inanmaktayýz.
Yöntem: Erciyes Üniversitesi Çocuk Alerji Polikliniði’ne 2015-2021 yýllarý arasýnda baþvurup anafilaksi tanýsý alan 0-18 yaþ aralýðýndaki hastalar çalýþmaya dahil edilmiþtir.
Bulgular: Hastalarýn çoðu erkek cinsiyetteydi. Ancak adolesan dönemdeki kýz cinsiyet aðýrlýðý dikkat çekiciydi (p<0.001). Tüm hastalarýn %86,9’unda (153) atopi varken % 25,56’sýnda alerjik olmayan kronik hastalýk mevcuttu. Besin iliþkili anafilaksi 49 hastada (% 27,84), ilaç iliþkili anafilaksi 41 hastada (% 23,29), venom iliþkili anafilaksi 62 hastada (% 35,22) ve idiyopatik anafilaksi hastalarýn 19ûnda geliþmiþti. Sistem tutulumlarý incelendiðinde sýrasýyla cilt/mukoza (% 91,47), solunum (% 72,15), gastrointestinal (% 40,34), kardiyovasküler sistem (% 20,45) ve sinir sistemi (% 17,04) tutulmuþtu. Ýlaç iliþkili anafilaksinin daha aðýr seyrettiði gözlendi (p=0.003). Antibiyotiklerin tetiklediði anafilaksi (p=0.002) ve eþek arýsý sokmasýyla geliþen anafilaksinin (p=0.003) ilk dakikada klinik bulgu vermesi çabuk geliþen reaksiyon açýsýndan anlamlýydý. Hastalarýn % 95,46’sýna intramuskuler adrenalin tedavisi uygulanmýþken % 4,54’ünün reaksiyon sonrasýnda uygun tedavi almadýðý gözlendi.
Sonuç: Anafilaksi tanýnýp uygun tedavi zamanýnda uygulandýðýnda tamamen geri dönüþlü bir reaksiyondur. Bu nedenle sýk görülen tetikleyiciler, risk faktörleri ve hastalýðýn tanýnmasý büyük öneme sahiptir. Bu çalýþma ile çocukluk çaðý anafilaksilerinde bu önemli faktörlere vurgu yapýlarak literature katkýda buluulmasý hedeflenmiþtir. (NCI-2024-3-12)