Evaluation of malnutrition in patients with febrile neutropenia

Objective: Febrile neutropenia is a critical condition in patients with malignancy, requiring oral and/or parenteral antibiotic treatment; and a significant cause of mortality and morbidity. It is well known that nutritional status is excessively impaired in these patients due to underlying disease itself along with the chemotherapeutics used. In this study we investigated nutritional status and general characteristics of patients admitted to our internal medicine clinic with febrile neutropenia.
Methods: Thirty patients who were followed up in the internal medicine service were included in the study. For the analysis of the data of the patients, height, weight, body mass index (BMI), weight loss in the last three months, albümin and total iron binding capacity values were recorded. Hand grip strength, mid-upper arm and mid-calf circumference measurements were obtained for the assessment of muscle strength; Mini Nutritional Assessment (MNA) and Nutrition Risk Screening 2002 (NRS 2002) scores were calculated at admission and discharge to evaluate nutritional status. Multinational Association of Supportive Care in Cancer (MASCC) score was used to identify risk and manage treatment.
Results: We included thirty patients (mean age 58,27± 16.52 years, 53% females). Of 30, six patients had lung cancer, four patients had myelodysplastic syndrome, three patients had stomach cancer, two patients had gastrointestinal system lymphoma, two patients had colon cancer, two patients had breast cancer, two patients had Non-Hodgkin`s lymphoma.
Conclusion: Majority of the patients, admitted to our internal medicine clinic, with febrile neutropenia were found to be malnourished; regardless of their risk classifications. Nutritional assessment scores of the majority were in the low-risk group. In conclusion, patients hospitalized with febrile neutropenia had poor nutritional status.

Febril nötropeni hastalarinda malnütrisyonun deðerlendirilmesi

Amaç: Febril nötropeni, maligniteli hastalarda oral ve/veya parenteral antibiyotik tedavisi gerektiren kritik bir durumdur ve önemli bir mortalite ve morbidite nedenidir. Bu hastalarda altta yatan hastalýðýn kendisi ve kullanýlan kemoterapötikler nedeniyle beslenme durumunun aþýrý derecede bozulduðu iyi bilinmektedir. Bu çalýþmada iç hastalýklarý kliniðimize febril neturopeni ile baþvuran hastalarýn beslenme durumlarý ve genel özellikleri araþtýrýlmýþtýr.
Yöntemler: Çalýþmaya dahiliye servisinde takip edilen 30 hasta dahil edildi. Hastalarýn verilerinin analizi için boy, kilo, vücut kitle indeksi (VKÝ), son üç aydaki kilo kaybý, albümin ve total demir baðlama kapasitesi deðerleri kaydedildi. Kas gücünü deðerlendirmek için el kavrama gücü, üst kol ve baldýr çevresi ölçümleri alýnmýþ; beslenme durumunu deðerlendirmek için Mini Nutrisyonel Deðerlendirme (MNA) ve Beslenme Risk Taramasý 2002 (NRS 2002) skorlarý baþvuru ve taburculuk sýrasýnda hesaplanmýþtýr. Multinational Association of Supportive Care in Cancer (MASCC) skoru riski belirlemek ve tedaviyi yönetmek için kullanýlmýþtýr.
Bulgular: Otuz hasta (ortalama yaþ 58,27± 16,52 yýl, %53 kadýn) çalýþmaya dahil edildi. Otuz hastanýn altýsýnda akciðer kanseri, dördünde miyelodisplastik sendrom, üçünde mide kanseri, ikisinde gastrointestinal sistem lenfomasý, ikisinde kolon kanseri, ikisinde meme kanseri, ikisinde Non-Hodgkin lenfoma vardý.
Sonuç: Dahiliye kliniðimize febril nötropeni ile baþvuran hastalarýn çoðunluðu, risk sýnýflandýrmalarýna bakýlmaksýzýn yetersiz beslenmiþ olarak bulunmuþtur. Çoðunluðun beslenme deðerlendirme skorlarý düþük risk grubundaydý. Sonuç olarak, febril nötropeni ile hastaneye yatýrýlan hastalarýn beslenme durumu kötüdür. (NCI-2024-2-13)