Low-molecular-weight heparin-associated multiple digital necrosis in a patient as a result of heparin-induced thrombocytopenia syndrome

Heparin-induced thrombocytopenia syndrome (HITS) is a rare complication of low-molecular-weight heparin (LMWH). It is an autoimmune-mediated side effect of LMWH which is caused by platelet-activating antibodies that recognize platelet factor-4/heparin complexes. Although HITS often leads to thrombosis in large veins and arteries, it can be presented as microvascular thrombosis. In this article, we report a case of HITS complicated with multiple digital necrosis after administration of LMWH.

Düþük moleküler aðýrlýklý heparin sonucu geliþen heparin kaynaklý trombositopeni sendromuna baðlý çoklu parmak nekrozu

Heparin kaynaklý trombositopeni sendromu (HKTS) düþük moleküler aðýrlýklý heparinin (DMAH) nadir bir komplikasyonudur. DMAH’nin trombosit faktör-4 / heparin komplekslerini tanýyan trombosit aktive edici antikorlarýn neden olduðu otoimmün aracýlý bir yan etkisidir. Her ne kadar HKTS büyük venlerde ve arterlerde tromboza yol açsa da, mikrovasküler tromboza da neden olabilmektedir. Bu yazýda, DMAH uygulanmasýndan sonra çoklu parmak nekrozu ile komplike olmuþ bir HKTS vakasýný sunmaktayýz. (NCI-2019-0282.R2)