Gastric hepatoid carcinoma: Report of a case
Metin Leblebici1, Cem Ilgın Erol1, Ozgur Ekinci1, Nesrin Gunduz2, Furkan Kilic1, Mehmet Acar1, Tunc Eren1, Rabia Burcin Girgin3, Orhan Alimoglu11Department of General Surgery, Istanbul Medeniyet University, Istanbul, Turkey2Department of Radiology, Istanbul Medeniyet University, Istanbul, Turkey
3Department of Pathology, Istanbul Medeniyet University, Istanbul, Turkey
Gastric hepatoid carcinoma (GHC) is a rare type of gastric cancer with a tendency to have poor prognosis and metastasize to the liver. GHCs generally show histopathologically hepatocellular differentiation and secrete alpha fetoprotein (AFP). AFP production can occur in cancers originating from the embryologically similar liver, gastrointestinal tract, and yolk sac and often metastasizes to the liver. Although GHC is aggressive, it may not always cause liver metastasis and may invade into the other abdominal organs by direct contact. In this article, we present a case of locally advanced GHC with high AFP levels.
Keywords: Alpha fetoprotein protein, gastric cancer; gastric diseases; human.Gastrik Hepatoid Karsinom: Olgu Sunumu
Metin Leblebici1, Cem Ilgın Erol1, Ozgur Ekinci1, Nesrin Gunduz2, Furkan Kilic1, Mehmet Acar1, Tunc Eren1, Rabia Burcin Girgin3, Orhan Alimoglu11İstanbul Medeniyet Üniversitesi, Genel Cerrahi Anabilim Dalı, İstanbul2Radyoloji Anabilim Dalı, İstanbul Medeniyet Üniversitesi, İstanbul
3İstanbul Medeniyet Üniversitesi, Patoloji Anabilim Dalı, İstanbul
Gastric Hepatoid Carcinoma (GHC) is a rare type of gatric cancer with a tendency to have poor prognosis and metastasize to the liver. GHCs generally show histopathologically hepatocellular differentiation and secrete Alpha Fetoprotein (AFP). AFP production can occur in cancers originating from the embryologically similar liver, gastrointestinal tract and yolk sac and often metastasizes to the liver. Although GHC is aggressive, it may not always cause liver metastasis and may invade into the other abdominal organs by direct contact. In this article, we present a case of locally advanced GHC with high AFP levels. (NCI-2019-0339.R1)
Anahtar Kelimeler: Gastric cancer, AFP protein, human, Gastric diseasesManuscript Language: English