Increase of endocan, a new marker for inflammation and endothelial dysfunction, in acute kidney injury

INTRODUCTION: In this study, the clinical relevance of the levels of serum endocan and 25-hydroxyvitamin D [25(OH)D] was investigated in patients with acute kidney injury (AKI). Endocan or the endothelial cell-specific molecule 1 is a soluble proteoglycan secreted by vascular endothelial cells. It plays a significant role in immunity, inflammation, and endothelial function.
METHODS: A total of 39 patients with AKI (19 females, 20 males) and 38 healthy individuals (18 females, 20 males) were included in the study. The levels of serum endocan, vitamin D, and other biochemical parameters were compared between the two groups.
RESULTS: In the AKI group, the values of serum creatinine, endocan, parathormone, phosphorus, and uric acid were found to be higher, and the total protein, albumin, and calcium levels were lower compared to the control group. There was no difference between the two groups in terms of the serum vitamin D, magnesium, alkaline phosphatase, and gamma-glutamyl transferase.
DISCUSSION AND CONCLUSION: In patients with AKI, an increased endocan level is a significant marker of inflammation and endothelial injury. In addition, these patients experience vitamin D deficiency.

Ýnflamasyon ve Endotel Disfonksiyonu için Yeni Bir Belirteç olan Endokan, Akut Böbrek Hasarýnda Artmaktadýr

GÝRÝÞ ve AMAÇ: Bu çalýþmada, akut böbrek hasarý (ABH) olan hastalarda, serum endokan ve 25-hidroksivitamin D [25 (OH) D] düzeyleri ve klinik olarak iliþkisi araþtýrýldý. Endokan veya endotel hücresine spesifik molekül 1 (ESM-1); immünite, inflamasyon ve endotel fonksiyonunda önemli bir rol oynayan vasküler endotel hücreleri tarafýndan salgýlanan çözünür bir proteoglikandýr.
YÖNTEM ve GEREÇLER: Toplam 39 ABH hastasý (19 kadýn, 20 erkek) ve 38 saðlýklý birey (18 kadýn, 20 erkek) çalýþmaya alýndý. Ýki grup arasýnda serum endokan, vitamin D ve diðer biyokimyasal parametrelerin seviyeleri karþýlaþtýrýldý.
BULGULAR: ABH grubunda serum kreatinin, endokan, parathormon, fosfor ve ürik asit deðerleri daha yüksek bulundu ve total protein, albümin ve kalsiyum seviyeleri kontrol grubuna göre daha düþüktü. Ýki grup arasýnda serum D vitamini, magnezyum, alkalin fosfataz ve gamma-glutamil transferaz açýsýndan fark yoktu.
TARTIÞMA ve SONUÇ: ABH olan hastalarda artmýþ endokan, inflamasyon ve endotel hasarýnýn göstergesidir. Buna ek olarak, bu hastalar D vitamini eksikliði çekmektedir.