An investigation into hemodynamically significant coronary artery lesions predictors assessed by fractional flow reserve: A propensity score matching analysis

OBJECTIVE: Fractional flow reserve (FFR) provides more useful information regarding myocardial metabolism and demand-supply convenience as compared to anatomical measurements. In this study, we aimed to investigate FFR predictors after propensity score matching (PSM) analysis in patients with intermediate coronary lesions.
METHODS: Patients who underwent coronary angiography between January 2014 and March 2015 due to suspicion of coronary artery disease were included in this study. Patients were divided into two groups according to the FFR status and predictors of FFR before and after PSM analysis were investigated.
RESULTS: A total of 290 patients (a total of 310 lesions) were included in this study (61±12 years, 75.5% male). In univariate analysis, after PSM analysis, Diameter stenosis (DS) and proximal LAD lesion (PLL) were associated with lower FFR values.
CONCLUSION: This study indicated that the majority of traditional FFR predictors did not reach the limit of significance after PSM analysis and we suggest that DS and PLL are one step ahead of predicting lesion severity compared to other traditional risk factors.

Fraksiyonel Akým Yedeði ile Ölçülen Ciddi Koroner Arter Darlýðýnýn Araþtýrýlmasý: Eðilim Skoru Eþleþtirme Analizi

GÝRÝÞ ve AMAÇ: Fraksiyonel akim rezervi (FFR) anatomik ölçümlere göre miyokardiyal metabolizma ve arz talep uyumu hakkýnda daha faydalý bilgiler verir ve biz ara lezyonu olan hastalarda FFR belirteçlerini eðilim skoru analizi ile araþtýrdýk.
YÖNTEM ve GEREÇLER: Ocak 2014 ile Mart 2015 yýllarý arasýnda koroner arter hastalýðý þüphesiyle anjiyografi yapýlmýþ ve ara koroner lezyon saptanan hastalar çalýþmaya alýndý. Hastalar FFR durumuna göre iki gruba ayrýlarak FFR belirteçleri PSM öncesi ve sonrasý araþtýrýldý.
BULGULAR: 290 hasta çalýþmaya alýnmýþtýr (yaþ ortalamasý 61±12, %75,5 erkek). PSM sonrasý tek deðiþkenli analizde diyamater stenoz (DS) ve proksimal LAD lezyonu(PLL) düþük FFR ile iliþkili bulundu.
TARTIÞMA ve SONUÇ: Bu çalýþmada geleneksel FFR belirteçlerinin PSM analizi sonrasý istatistiksel anlamlýlýk sýnýrýna ulaþmadýðýný gösterdik ve biz lezyon ciddiyetinin tahmininde PLL ve (DS)’nin diðer belirteçlere göre bir adým daha önde olduðunu düþünüyoruz. (NCI-2018-0030.R1)