ISSN: 2148-4902 | E-ISSN: 2536-4553
Northern Clinics of Istanbul A case study of methadone-induced delayed post-hypoxic leukoencephalopathy with improvement by antioxidant therapy [North Clin Istanb]
North Clin Istanb. 2021; 8(1): 106-108 | DOI: 10.14744/nci.2020.29795

A case study of methadone-induced delayed post-hypoxic leukoencephalopathy with improvement by antioxidant therapy

Atousa Hakamifard1, Somayeh Hajiahmadi2, Fariborz Khorvash3, Sima Azish4
1Department of Infectious Diseases, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Radiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4Department of Cardiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Delayed post-hypoxic leukoencephalopathy (DPHL) is a syndrome that may occur as a result of the hypoxic event, including opiate overdose. The pathophysiology of this entity is not fully known. Within a neuropsychiatric context, the diagnosis of this rare disease is important. A 39-year-old man with a history of methadone overdose presented with loss of consciousness and fever. After clinical evaluations, laboratory analysis, including various tests on blood and cerebrospinal fluid and magnetic resonance imaging, the patient was diagnosed with methadone-induced DPHL. Treatment with antioxidants, including vitamins E, C and B complex, produced a favorable outcome. In rare cases, methadone overdose may lead to DPHL. Antioxidants therapy should be considered in the treatment of this rare disorder. (NCI-2018-0092.R3)

Keywords: Antioxidants, anoxia; delayed post-hypoxic leukoencephalopathy; hypoxia; leukoencephalopathy; methadone; overdose; vitamin.

Atousa Hakamifard, Somayeh Hajiahmadi, Fariborz Khorvash, Sima Azish. A case study of methadone-induced delayed post-hypoxic leukoencephalopathy with improvement by antioxidant therapy. North Clin Istanb. 2021; 8(1): 106-108

Corresponding Author: Atousa Hakamifard
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